Patient Safety Resources - Drug Safety
Drug – Drug Interaction (DDI) Resources
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Medications Quality & Safety Notes
(a monthly news update - pdfs) |
QMIS Measure Specification: Measure ID:10507
https://www.qualitynet.org/qmis/measureDetailView.htm?measureId=10507&viewType=0
Numerator: The number of Part D enrollees in the denominator with >1 DDI in Prescription Drug Event (PDE) claims during the measurement period.
Denominator: The number of Part D enrollees with PDE claims for at least one of the object or precipitant drugs selected for DDI during the measurement period.
- Object Drug – the drug in which effects or pharmacokinetics are impacted by subsequent administration of another drug (precipitant drug)
- Precipitant Drug – the drug which triggers the change in effects or pharmacokinetics of another drug being administered (object drug)
- Drug-Drug Interaction (DDI) - A drug-drug interaction can be defined as the phenomenon that occurs when the effects or pharmacokinetics of a drug are altered by prior administration of another drug. A DDI event is defined as the presence of pharmacy claims for overlapping days supply for the object and precipitant drugs.
- Table 2 DDI [pdf]
Intervention Tools
Additional Resources
Measuring Patient Safety in Ambulatory Care: Potential for Identifying Medical Group Drug-Drug Interaction Rate Using Claims Data. Am J Manag Care 2004;10:753-59. http://www.ajmc.com/issue/managed-care/2004/2004-11-vol10-n11Pt1/Nov04-1941p753-759
DDI ACEI/ARB – potassium sparing diuretics
Evidence based literature - use of these drug combinations in CHF
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure (Randomized Aldactone Evaluation Study, RALES)
http://content.nejm.org/cgi/content/short/341/10/709
Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction
(Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study, EPHESUS)
http://content.nejm.org/cgi/content/short/348/14/1309
Warfarin Tool Kit
AHRQ Warfarin Booklet
- Your Guide to Coumadin®/Warfarin Therapy
http://www.ahrq.gov/consumer/coumadin.htm - Su guía para el tratamiento con Coumadin®/warfarina (Spanish/Espanol)
http://www.ahrq.gov/consumer/coumadinsp.htm - Blood Thinner Pills Using Them Safely – a video and booklet in English and Spanish
http://www.ahrq.gov/consumer/btpills.htm
Requests for copies of Your Guide to Coumadin/Warfarin Therapy booklet (AHRQ pub no. 08-0028-A/English or AHRQ pub no. 08-0028-B/Spanish), should be directed to the AHRQ publications clearinghouse via e-mail at AHRQpubs@ahrq.hhs.gov or via phone toll-free at 800-358-9295.
The first 100 copies for healthcare organizations/providers are free!
BULK PRICING:
Requests for bulk copies should be sent to the AHRQ Publication Clearinghouse via e-mail at AHRQPubs@ahrq.hhs.gov.
Delmarva Foundation Warfarin Alert Card/Key FobThe .zip links below contain the English/Spanish version:
Production-ready Adobe Illustrator Templates |
A Patient's Guide to Taking Coumadin/Warfarin
http://circ.ahajournals.org/cgi/content/full/119/8/e220?eaf
Blood Thinners, Staying Safe and Healthy While Using Warfarin
http://jeny.ipro.org/showthread.php?t=2396
Warfarin Interactive Tutorial in Spanish (Espanol) – help Spanish speaking patients understand their warfarin therapy – hosted by the National Library of Medicine
http://www.nlm.nih.gov/medlineplus/spanish/tutorials/coumadinintroductionspanish/htm/index.htm
A Tool to Assist Clinicians in Dosing Warfarin Therapy - supported by the Barnes-Jewish Hospital at Washington University Medical Center, the NIH, and donations
http://www.warfarindosing.org/Source/Home.aspx
